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Dosage & treatment for Infections: Adults and Children >12 years: Usually 1.2 g 8 hourly. In more serious infections, increase frequency to 6-hourly intervals.
Children 3 months to 12 years: Usually 30 mg/kg* 8 hourly. In more serious infections, increase frequency to 6-hourly intervals.
Children 0-3 months: 30 mg/kg* every 12 hrs in premature infants and in full-term infants during the perinatal period, increasing to 8 hrs thereafter.
*Each 30-mg Co-Amoxiclav contains amoxicillin 25 mg and clavulanic acid 5 mg.
Dosage for Surgical Prophylaxis: Adults: The usual dose is Co-Amoxiclav 1.2 g at the induction of anesthesia. Operations where there is a high risk of infection e.g., colorectal surgery, may require 3, and up to 4 doses of Co-Amoxiclav 1.2 g in a 24-hr period. These doses are usually given at 0, 8, 16 (and 24) hrs. This regimen can be continued for several days if the procedure has a significantly increased risk of infection.
Clear clinical signs of infection at operation will require a normal course of IV or oral Co-Amoxiclav therapy postoperatively.
Renal Impairment: Adults: Mild Impairment (creatinine clearance >30 mL/min): No change in dosage.
Moderate Impairment (creatinine clearance 10-30 mL/min): 1.2 g IV stat, followed by 600 mg IV 12 hourly.
Severe Impairment (creatinine clearance <10 mL/min): Adult: 1.2 g IV stat, followed by 600 mg IV 24 hourly. Dialysis decreases serum concentrations of Co-Amoxiclav and an additional 600-mg IV dose may need to be given during dialysis and at the end of dialysis.
Children: Similar reductions in dosage should be made.
Hepatic Impairment: Dose with caution; monitor hepatic function at regular intervals.
Each 1.2-g vial Co-Amoxiclav contains 1 mmol of potassium and 3.1 mmol of sodium (approximately).
